منابع مشابه
Novel Vaccine Delivery Technology
Infections of the respiratory and GI tracts are among the most common diseases of piglets worldwide and cause substantial economic loss to swine producers. Effective immunity to these infections needs a specific response at the surface of the tract (Bozic et al., 2002). However vaccine formulation and delivery to these surfaces remains a major challenge. Recent evidence of this type of immune r...
متن کاملNovel Vaccine Approaches
Shiver (Abstract S4) reviewed the strategy that he and his colleagues have developed for standardized assessment of T cells through development of short-term stimulation with peptide pools and ELISPOT assays that detect cytokine-secreting cells. Studies in HIV-infected individuals showed that ELISPOT assays can reproducibly and quantitatively measure cell-mediated responses to a variety of HIV ...
متن کاملNanobiotechnological approaches to delivery of DNA vaccine against fungal infection.
Vaccines play an essential role in keeping humans healthy. Innovative approaches to their use include the utilization of plasmid DNA encoding sequences to express foreign antigens. DNAhsp65 from Mycobacterium leprae is suitable for this purpose due to its ability to elicit a powerful immune response. Controlled release systems represent a promising approach to delivering vaccines. In this work,...
متن کاملCurrent and novel approaches to vaccine development against tuberculosis
Antibiotics and vaccines are the two most successful medical countermeasures that humans have created against a number of pathogens. However a select few e.g., Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB) have evaded eradication by vaccines and therapeutic approaches. TB is a global public health problem that kills 1.4 million people per year. The past decade has s...
متن کاملLarge screen approaches to identify novel malaria vaccine candidates.
Until recently, malaria vaccine development efforts have focused almost exclusively on a handful of well characterized Plasmodium falciparum antigens. Despite dedicated work by many researchers on different continents spanning more than half a century, a successful malaria vaccine remains elusive. Sequencing of the P. falciparum genome has revealed more than five thousand genes, providing the f...
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ژورنال
عنوان ژورنال: Pharmaceutical Research
سال: 2004
ISSN: 0724-8741
DOI: 10.1023/b:pham.0000041443.17935.33